X-Chromosomal Translocation and Segmental Hypopigmentation — NEJM  hypomelanosis of Ito

X-Chromosomal Translocation and Segmental Hypopigmentation — NEJM hypomelanosis of Ito

Chromosomal translocation & associated neoplasms...

Chromosomal translocation & associated neoplasms...

Scientists decipher the molecular basis of an as yet incurable leukemia in children - Although intensive research over the least decade has led to significant improvement of the survival rates of children suffering from ALL, a subset of patients still remains resistant to treatment. One such example is a very aggressive and incurable subtype associated with a t(17;19) chromosomal translocation, which occurs due to breakage and aberrant fusion of genetic material in the tumour cells…

Scientists decipher the molecular basis of an as yet incurable leukemia in children - Although intensive research over the least decade has led to significant improvement of the survival rates of children suffering from ALL, a subset of patients still remains resistant to treatment. One such example is a very aggressive and incurable subtype associated with a t(17;19) chromosomal translocation, which occurs due to breakage and aberrant fusion of genetic material in the tumour cells…

The chromosomal translocation characteristic of 70 percent of MCL(Mantel Cell Lymphoma) cases occurs between chromosomes 11 and 14 resulting in the overexpression of cyclinD1

The chromosomal translocation characteristic of 70 percent of MCL(Mantel Cell Lymphoma) cases occurs between chromosomes 11 and 14 resulting in the overexpression of cyclinD1

Ewing/PNET characteristic t(11;22) (q24;q12) leading to EWS-FLI1 fusion is encountered in 85% of Ewing Sarcoma/PNET cases. The majority of remaining cases (10-15%) demonstrate fusion of the EWS gene with a second member of the ETS family of genes, namely ERG. The EWS-ERG fusion occurs as a result of chromosomal translocation t(21;22)(q22;q12)

Ewing/PNET characteristic t(11;22) (q24;q12) leading to EWS-FLI1 fusion is encountered in 85% of Ewing Sarcoma/PNET cases. The majority of remaining cases (10-15%) demonstrate fusion of the EWS gene with a second member of the ETS family of genes, namely ERG. The EWS-ERG fusion occurs as a result of chromosomal translocation t(21;22)(q22;q12)

Chromosomal translocation...

Chromosomal translocation...

Janet Rowley - Discover of chromosomal translocations leading to disease.  Did this at the University of Chicago while working part time and raising her family.  Awarded Presidential Medal of Freedom by Barak Obama

Janet Rowley - Discover of chromosomal translocations leading to disease. Did this at the University of Chicago while working part time and raising her family. Awarded Presidential Medal of Freedom by Barak Obama

Image result for chromosomal translocation

Image result for chromosomal translocation

Images in Clinical Medicine from The New England Journal of Medicine — X-Chromosomal Translocation and Segmental Hypopigmentation

Images in Clinical Medicine from The New England Journal of Medicine — X-Chromosomal Translocation and Segmental Hypopigmentation

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