The 4 stages of mitosis are: — prophase: chromosomes become visible and the nuclear membrane disappears — metaphase: double-chromatid chromosomes align along the nuclear equator — anaphase: chromatids separate and each chromatid is pulled toward a daughter cell nucleus — telophase: nuclear membranes reappear and chromosomes become indistinct as interphase ensues.
'Previously, the nuclear membrane was thought to be mostly just a protective bubble around the nuclear material, with pores acting as channels to transport molecules in and out. But in a study published on October 26 in Nature Cell Biology, a research team led by Irene Chiolo documents how broken strands of a portion of DNA known as heterochromatin are dragged to the nuclear membrane for repair.' Nuclear membrane repairs the 'dark matter' of DNA:
Nuclear Membrane Pattern: Antibodies to nuclear membrane can be difficult to identify. Testing on mouse stomach kidney substrate (MSK) can be helpful. As the MSK tissue is cut into thin sections, the nuclei of cells are often transected. The outer membrane layer on cross sectioned nuclei will stain, giving a distinct rim pattern.
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