Lappaconitine, extracted form the roots of Aconitum carmichaeli Debx, has neurotoxic, cardiotoxic and strong analgesic activities that does not involve the opioid receptor, and further suggest that the central nervous system may be involved in the action
A cellular mechanism has been discovered by which kappa opioid receptors (KORs) drive anxiety. These proteins inhibit the release of the neurotransmitter glutamate in a part of the brain that regulates emotion. KORs are targets for the treatment of addiction and anxiety disorders.
Light -- not pain-killing drugs -- used to activate brain's opioid receptors
Medical Science,Science News,Opioid Receptor,Neuroscience,The Brain,Science Nature,Neurology,Spinal Cord,St Louis
Pain patients who do not respond to the analgesic properties of opioids have a chance of being genetically incapable of generating the clinically active metabolite of these medications. Get tips on when to suspect a patient has CYP-2D6 deficiency.