Design and synthesis of aminoester heterodimers containing flavone or chromone moieties as modulators of P-glycoprotein-based multidrug resistance (MDR)

Design and synthesis of aminoester heterodimers containing flavone or chromone moieties as modulators of P-glycoprotein-based multidrug resistance (MDR)

Dual inhibitors of the human blood-brain barrier drug efflux transporters P-glycoprotein and ABCG2 based on the antiviral azidothymidine

Dual inhibitors of the human blood-brain barrier drug efflux transporters P-glycoprotein and based on the antiviral azidothymidine

Continuous Sorting of Cells Based on Differential P Selectin Glycoprotein Ligand Expression Using Molecular Adhesion

Continuous Sorting of Cells Based on Differential P Selectin Glycoprotein Ligand Expression Using Molecular Adhesion

Microscopic HUMAN egg. Color-enhanced. "The egg is coated with the zone pellicuda, a glycoprotein that protects the egg but also helps to trap and bind sperm. Two coronal cells are attached to the zone pellicuda."

This image is of a purple, colour-enhanced human egg sitting on a pin. The egg is coated with the zona pellicuda, a glycoprotein that protects the egg but also helps to trap and bind sperm. Two coronal cells are attached to the zona pellicuda.

A novel delocalized lipophilic cation-chlorambucil conjugate inhibits P-glycoprotein in HepG2/ADM cells

A novel delocalized lipophilic cation-chlorambucil conjugate inhibits P-glycoprotein in cells

Sucralose, A Synthetic Organochlorine Sweetener: Overview Of Biological IssuesThis review of the scientific literature on sucralose (Splenda) is cause for concern. Some of the biological effects of sucralose include:~ alterations in insulin, blood glucose, and glucagon-like peptide 1 (GLP-1) levels,~ metabolism of sucralose in the gastrointestinal tract to metabolites whose identity and safety profile are unknown,~ induction of cyctochrome P450 and P-glycoprotein in the gastrointestinal ...

Sucralose, A Synthetic Organochlorine Sweetener: Overview Of Biological Issues

Strategy Developed to Improve Delivery of Medicines to the Brain - The experimental treatment method allows small therapeutic agents to safely cross the blood-brain barrier in laboratory rats by turning off P-glycoprotein, one of the main gatekeepers preventing medicinal drugs from reaching their intended targets in the brain.

Strategy Developed to Improve Delivery of Medicines to the Brain

Multidrug ABC transporter, P-glycoprotein (with sound)

Multidrug ABC transporter, P-glycoprotein (with sound)

Figure 3: Unhealthy diets such as high fat diets downregulate hepatic drug metabolism with the corruption of insulin therapy in diabetes and aging. Amyloid beta metabolism in the brain and liver are connected to drug metabolism and defective hepatic drug metabolism may be the primary defect in Type 3 diabetes with acceleration of neuronal apoptosis by abnormal brain amyloid beta metabolism associated with Type 1 or Type 2 diabetes. Abbreviations: P-gp1, P glycoprotein, PXR, pregnane X…

Diet and Nutrition Reverse Type 3 Diabetes and Accelerated Aging Linked to Global Chronic Diseases

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