Strategy Developed to Improve Delivery of Medicines to the Brain - The experimental treatment method allows small therapeutic agents to safely cross the blood-brain barrier in laboratory rats by turning off P-glycoprotein, one of the main gatekeepers preventing medicinal drugs from reaching their intended targets in the brain.

Strategy Developed to Improve Delivery of Medicines to the Brain

Sucralose, A Synthetic Organochlorine Sweetener: Overview Of Biological Issues

Sucralose, A Synthetic Organochlorine Sweetener: Overview Of Biological Issues. Journal of Toxicology and Environmental Health, Part B: Vol.

Antibodies and their antigen. Computer model showing the molecular structure of two anti-P-glycoprotein antibodies (upper left and right) and the P-glycoprotein (blue) to which they respond. These antibodies will bind to the glycoprotein, preventing it from functioning.  ©Laguna Design/Science Source

SP8395: Antibodies and their antigen

Multidrug ABC transporter, P-glycoprotein (with sound)

P-glycoprotein removes anticancer drugs from cytoplasm and confers multidrug resistance to cancer cells.

Figure 3: Unhealthy diets such as high fat diets downregulate hepatic drug metabolism with the corruption of insulin therapy in diabetes and aging. Amyloid beta metabolism in the brain and liver are connected to drug metabolism and defective hepatic drug metabolism may be the primary defect in Type 3 diabetes with acceleration of neuronal apoptosis by abnormal brain amyloid beta metabolism associated with Type 1 or Type 2 diabetes. Abbreviations: P-gp1, P glycoprotein, PXR, pregnane X…

Diet and Nutrition Reverse Type 3 Diabetes and Accelerated Aging Linked to Global Chronic Diseases

A novel delocalized lipophilic cation-chlorambucil conjugate inhibits P-glycoprotein in HepG2/ADM cells

A novel delocalized lipophilic cation-chlorambucil conjugate inhibits P-glycoprotein in HepG2/ADM cells

Is MS lots of different conditions    Jarius S König FB Metz I Ruprecht K Paul F Brück W Wildemann B.Pattern II and pattern III MS are entities distinct from pattern I MS: evidence from cerebrospinal fluid analysis.J Neuroinflammation. 2017; 14(1):171. BACKGROUND:The diagnosis of multiple sclerosis (MS) is currently based solely on clinical and magnetic resonance imaging features. However histopathological studies have revealed four different patterns of lesion pathology in patients…

Is MS lots of different conditions Jarius S König FB Metz I Ruprecht K Paul F Brück W Wildemann B.Pattern II and pattern III MS are entities distinct from pattern I MS: evidence from cerebrospinal fluid analysis.J Neuroinflammation. 2017; 14(1):171. BACKGROUND:The diagnosis of multiple sclerosis (MS) is currently based solely on clinical and magnetic resonance imaging features. However histopathological studies have revealed four different patterns of lesion pathology in patients…

Inhibition of p-glycoprotein by quinidine increasing concentration of digoxin

Inhibition of p-glycoprotein by quinidine increasing concentration of digoxin

P-Glycoprotein

P-Glycoprotein

How Splenda makes you fat. Splenda reduces the amount of good bacteria in the intestines by 50%, increases the pH level in the intestines, contributes to increases in body weight and affects the P-glycoprotein (P-gp) in the body in such a way that crucial health-related drugs could be rejected"  How much Splenda caused this? It was the equivalent of 7 packets. Over time and daily use this could have extreme consequences’ on ones health and weight.

Do you put Splenda in your coffee? Or use it in your baked goods, instead of regular sugar or other natural alternatives? You may think you are making a better choice, but in fact, you are doing more harm than good. Many foods labeled as "healthier f

ABC Transporter Pgp-1 ( P-glycoprotein-1) - YouTube

We want to outline how this membrane transporter found in nearly every human cell is involved in human cancer multi-drug resistance. We examine crystal struc.

Splenda alters gut microflora and increases intestinal p-glycoprotein and…

Splenda alters gut microflora and increases intestinal p-glycoprotein and cytochrome in male rats.

Egyetlen pohár grapefruit dzsúsz legalább ötven százalékkal megnöveli a Q10 koenzim (CoQ10) felszívódási arányát a bélrendszerből – mutatta ki egy idén publikált japán tanulmány. A dzsúsz a sejtmembránban található P-glycoprotein (P-gp) nevű fehérje működését befolyásolja, aminek eredményeként megnőtt a sejtek Q10 felvétele a laboratóriumi kísérletek során. “Azt találtuk, hogy grapefruit dzsúsz jelenlétében megnő a sejtek CoQ10 […]

Egyetlen pohár grapefruit dzsúsz legalább ötven százalékkal megnöveli a Q10 koenzim (CoQ10) felszívódási arányát a bélrendszerből – mutatta ki egy idén publikált japán tanulmány. A dzsúsz a sejtmembránban található P-glycoprotein (P-gp) nevű fehérje működését befolyásolja, aminek eredményeként megnőtt a sejtek Q10 felvétele a laboratóriumi kísérletek során. “Azt találtuk, hogy grapefruit dzsúsz jelenlétében megnő a sejtek CoQ10 […]

Piperine is an alkaloid extracted from black pepper (P. nigrum) and long pepper (P. longum). Previous studies have shown that piperine has anti-inflammatory, antiarthritic and anti-depressant effects [8] [9]. Piperine has also been known to inhibit CYP3A4 and P-glycoprotein due to which it has been used to enhance the bioavailability of other drugs [10]. When co-administered with curcumin, piperine increased the bioavailability of curcumin by 2000% [11]. In a clinical study, simultaneous…

In this study, we determined the cytotoxic effects of piperine, a major constituent of black and long pepper in melanoma cells. Piperine treatment inhibited the growth of SK MEL 28 and cells in a dose and time-dependent manner.

Toxicology of Avermectins and Milbemycins (Macrocylic Lactones) and the Role of P-Glycoprotein in Dogs and Cats

Toxicology of Avermectins and Milbemycins (Macrocylic Lactones) and the Role of P-Glycoprotein in Dogs and Cats

P-glycoprotein - Wikipedia

Cannabis Can Paradoxically Worsen Pain - Prof of Pot

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