Strategy Developed to Improve Delivery of Medicines to the Brain - The experimental treatment method allows small therapeutic agents to safely cross the blood-brain barrier in laboratory rats by turning off P-glycoprotein, one of the main gatekeepers preventing medicinal drugs from reaching their intended targets in the brain.

Strategy Developed to Improve Delivery of Medicines to the Brain

Antibodies and their antigen. Computer model showing the molecular structure of two anti-P-glycoprotein antibodies (upper left and right) and the P-glycoprotein (blue) to which they respond. These antibodies will bind to the glycoprotein, preventing it from functioning.  ©Laguna Design/Science Source

SP8395: Antibodies and their antigen

Figure 3: Unhealthy diets such as high fat diets downregulate hepatic drug metabolism with the corruption of insulin therapy in diabetes and aging. Amyloid beta metabolism in the brain and liver are connected to drug metabolism and defective hepatic drug metabolism may be the primary defect in Type 3 diabetes with acceleration of neuronal apoptosis by abnormal brain amyloid beta metabolism associated with Type 1 or Type 2 diabetes. Abbreviations: P-gp1, P glycoprotein, PXR, pregnane X…

Diet and Nutrition Reverse Type 3 Diabetes and Accelerated Aging Linked to Global Chronic Diseases

A novel delocalized lipophilic cation-chlorambucil conjugate inhibits P-glycoprotein in HepG2/ADM cells

A novel delocalized lipophilic cation-chlorambucil conjugate inhibits P-glycoprotein in HepG2/ADM cells

Multidrug ABC transporter, P-glycoprotein (with sound)

P-glycoprotein removes anticancer drugs from cytoplasm and confers multidrug resistance to cancer cells.

Is MS lots of different conditions    Jarius S König FB Metz I Ruprecht K Paul F Brück W Wildemann B.Pattern II and pattern III MS are entities distinct from pattern I MS: evidence from cerebrospinal fluid analysis.J Neuroinflammation. 2017; 14(1):171. BACKGROUND:The diagnosis of multiple sclerosis (MS) is currently based solely on clinical and magnetic resonance imaging features. However histopathological studies have revealed four different patterns of lesion pathology in patients…

Is MS lots of different conditions Jarius S König FB Metz I Ruprecht K Paul F Brück W Wildemann B.Pattern II and pattern III MS are entities distinct from pattern I MS: evidence from cerebrospinal fluid analysis.J Neuroinflammation. 2017; 14(1):171. BACKGROUND:The diagnosis of multiple sclerosis (MS) is currently based solely on clinical and magnetic resonance imaging features. However histopathological studies have revealed four different patterns of lesion pathology in patients…

Superfood Green ~ 400 Capsules ~ 9 Cents/Cap ~ Spirulina & Alfalfa - Doctor Developed ~ Extra Large Bottle:   strongSuperfood Greens is a combination of Spirulina and Alfalfa.  Dr. Nelson has been using this combination to solve many health issues throughout the years./strong/p strong  /strong/p strongUnlike other algaes, the cell wall of spirulina has high concentrations of mucopolysaccharides, which are easily digested and form glycoprotein complexes that are important in the formati...

Superfood Green ~ 400 Capsules ~ 9 Cents/Cap ~ Spirulina & Alfalfa - Doctor Developed ~ Extra Large Bottle: strongSuperfood Greens is a combination of Spirulina and Alfalfa. Dr. Nelson has been using this combination to solve many health issues throughout the years./strong/p strong /strong/p strongUnlike other algaes, the cell wall of spirulina has high concentrations of mucopolysaccharides, which are easily digested and form glycoprotein complexes that are important in the formati...

Sucralose, A Synthetic Organochlorine Sweetener: Overview Of Biological Issues

Sucralose, A Synthetic Organochlorine Sweetener: Overview Of Biological Issues. Journal of Toxicology and Environmental Health, Part B: Vol.

Inhibition of p-glycoprotein by quinidine increasing concentration of digoxin

Inhibition of p-glycoprotein by quinidine increasing concentration of digoxin

P-Glycoprotein

P-Glycoprotein

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