Mutations of the PTEN gene have long been linked with cancer. Recently, however, researchers at the Cleveland Clinic have found that PTEN mutations are found in a small subgroup (about 1-2%) of children who have autism.

Clinic research on rare type of autism linked to PTEN gene reveals potential clues to the brain disorder

Mutations of the PTEN gene have long been linked with cancer. Recently, however, researchers at the Cleveland Clinic have found that PTEN mutations are found in a small subgroup (about of children who have autism.

What is Oppositional Defiant Disorder (ODD) - Symptoms & Statistics

What is Oppositional Defiant Disorder (ODD) - Symptoms & Statistics

Blog: PTEN Gene for Concerned Parents... There is so much to tell!  Cameron is 3 years, 3 months old and he is a smart boy!  Cam has been said to have PTEN Macrocephaly Autism:  a mutation of his PTEN gene, which is from what I understand the tumor suppressor gene.  To me, this means that without proper function of the gene, cells can grow quickly - both good cells and bad cells. http://ptenparents.blogspot.co.uk/. Last blog post: 02.2013

Blog: PTEN Gene for Concerned Parents... There is so much to tell! Cameron is 3 years, 3 months old and he is a smart boy! Cam has been said to have PTEN Macrocephaly Autism: a mutation of his PTEN gene, which is from what I understand the tumor suppressor gene. To me, this means that without proper function of the gene, cells can grow quickly - both good cells and bad cells. http://ptenparents.blogspot.co.uk/. Last blog post: 02.2013

The Dual Life of PTEN: Gene Mutations Contribute to Both Cancer and Birth Defects on Cowden's Syndrome, Bannayan-Riley-Ruvalcaba Syndrome, PTEN Hamartoma Tumour Syndrome. curated by Emmi Dack

The Dual Life of PTEN: Gene Mutations Contribute to Both Cancer and Birth Defects

The Dual Life of PTEN: Gene Mutations Contribute to Both Cancer and Birth Defects on Cowden's Syndrome, Bannayan-Riley-Ruvalcaba Syndrome, PTEN Hamartoma Tumour Syndrome. curated by Emmi Dack

Genes a/w Follicular & Medullary carcinoma thyroid ... #P53 #PTEN #RAS #PAX8 #RET

Genes a/w Follicular & Medullary carcinoma thyroid ... #P53 #PTEN #RAS #PAX8 #RET

An atypical patient with Cowden syndrome and PTEN gene mutation presenting with cortical malformation and focal epilepsy...  CS has been rarely reported in association with a cortical malformation or epilepsy... These cases suggest that cortical dysplasia needs to be suspected when a CS patient presents with drug-resistant seizures.    http://www.brainanddevelopment.com/article/S0387-7604(12)00070-8/abstract  Image…

Para que serve o eletroencefalograma

Paediatric inflammatory bowel diseases (IBD):  The researchers targeted the PTEN gene ... “No one thought that PTEN was associated with IBD,” Dr. Rhee says. “But we hypothesized that it might have something to do with the pathogenesis because the intestinal epithelial cell needs to be readily proliferated to maintain the integrity of the intestine, and the key factor controlling this cell proliferation is the PTEN gene.” gastro.ucla.edu workfiles newsletters BTSFall2014Final.pdf

Gastroenterology: The UCLA Vatche & Tamar Manoukian Division of Digestive Diseases in Los Angeles is a world leader in the diagnosis, treatment, and research aimed at combating debilitating and deadly disorders affecting the gastrointestinal tract.

Cowden's syndrome/BRRS. Each PTEN gene mutation case is different.  Nathaniel does not have autism, down-slanted eyes, or...  He has two tiny skin-colored bumps on his fingers (acral keratoses), these would go unnoticed by most people... he had hundreds of polyps in his small intestine...   I had inquired about seeking a genetics evaluation several times, but each time I was told that it was probably not necessary.   http://ptenlife.com/nathaniels-story/

Cowden's syndrome/BRRS. Each PTEN gene mutation case is different. Nathaniel does not have autism, down-slanted eyes, or... He has two tiny skin-colored bumps on his fingers (acral keratoses), these would go unnoticed by most people... he had hundreds of polyps in his small intestine... I had inquired about seeking a genetics evaluation several times, but each time I was told that it was probably not necessary. http://ptenlife.com/nathaniels-story/

Thyroid Cancer: Does It Run in the Family? – Health Essentials from Cleveland Clinic

Thyroid Cancer: Does It Run in the Family?

Thyroid Cancer: Does It Run in the Family? – Health Essentials from Cleveland Clinic

SOLAMEN syndrome is caused by a mutation in the PTEN gene  (Segmental overgrowth, lipomatosis, arteriovenous malformation and epidermal nevus).

SOLAMEN syndrome is caused by a mutation in the PTEN gene (Segmental overgrowth, lipomatosis, arteriovenous malformation and epidermal nevus).

When Emma was about a year we had been noticing things didn’t come so easy for her. She wasn’t as far developmentally as she should have been...the doctor diagnosed autism... we had lots of bloodwork done  and it came back that Emma had a PTEN gene mutation.  http://ptenlife.com/emmas-story/

Life with a PTEN Mutation that results in Bannayan Riley Ruvalcaba Syndrome, Cowdens Syndrome or Autism

Dermoscopy of Cowden syndrome.. 'We describe 4 patients with known mutations in the PTEN gene (OMIM 158350) to illustrate the use of dermoscopy and the histologic appearance of palmar lesions in Cowden syndrome.' http://archderm.jamanetwork.com/article.aspx?articleid=711998

Dermoscopy of Cowden syndrome.. 'We describe 4 patients with known mutations in the PTEN gene (OMIM 158350) to illustrate the use of dermoscopy and the histologic appearance of palmar lesions in Cowden syndrome.' http://archderm.jamanetwork.com/article.aspx?articleid=711998

A little redundancy can be a good thing. A team of researchers led by Dr. Kevin Morris at the Scripps Institute, in La Jolla, recently showed that a little redundancy in the regulation of PTEN, a tumor suppressor gene, can be pretty useful…but also really complicated.    PTENpg1, a PTEN pseudogene, regulates PTEN via both sense and antisense RNAs, and there’s a histone modification in the mix, too.    PTEN gets silenced in lots of cancers. The team from Sweden, the U.S., and Australia…

PTEN is a tumor-suppressor gene that has been shown to be under the regulatory control of a PTEN pseudogene expressed noncoding RNA, Here, researchers at the Karolinska Institutet, [.

Researchers have unraveled a role for tumor suppressor genes in restricting the growth of neighboring cell populations. The study might have implications for understanding the early events of tumorigenesis and the selection of the tumour-initiating cells.  Depletion of the PTEN tumour suppressor gene induces tissue overgrowth and reduces the growth of the neighbouring cell population in Drosophila wing primordia.

Tumour suppressor genes curb growth in neighboring cells

Researchers have unraveled a role for tumor suppressor genes in restricting the growth of neighboring cell populations. The study might have implications for understanding the early events of tumorigenesis and the selection of the tumour-initiating cells.

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