Giant liposomes of pulmonary surfactant (40x)

Jorge Bernardino de la Serna MEMPHYS - Center for Biomembrane Physics University of Southern Denmark Odense, Denmark Giant liposomes of pulmonary surfactant

Dr. Jorge Bernardino de la Serna    MEMPHYS - Center for Biomembrane Physics, Department of Biochemistry and Molecular Biology  University of Southern Denmark  Odense, Denmark    Giant liposomes of pulmonary surfactant (40x)    Confocal

Jorge Bernardino de la Serna MEMPHYS - Center for Biomembrane Physics, Department of Biochemistry and Molecular Biology University of Southern Denmark Odense, Denmark Giant liposomes of pulmonary surfactant Confocal

Mesoporous carbon nanomaterials induced pulmonary surfactant inhibition cytotoxicity inflammation and lung fibrosis

Mesoporous carbon nanomaterials induced pulmonary surfactant inhibition cytotoxicity inflammation and lung fibrosis

Zoomfa.com - Questions about Marsh, first question: What is In geography a marsh , or morass ,? - Automatic Question and Answers Generation System

Zoomfa.com - Questions about Marsh, first question: What is In geography a marsh , or morass ,? - Automatic Question and Answers Generation System

There are around 150 million alveoli in a human lung. 95% of the alveolar surface area is made of squamous (type I) alveolar cells which allow for gas diffusion between air and blood and 5% of great (type II) alveolar cells which are cuboidal shaped and repair the alveolar epithelium and secrete pulmonary surfactant. Pulmonary surfactant coats the alveoli &small bronchioles and prevents collapsing.

There are around 150 million alveoli in a human lung. 95% of the alveolar surface area is made of squamous (type I) alveolar cells which allow for gas diffusion between air and blood and 5% of great (type II) alveolar cells which are cuboidal shaped and repair the alveolar epithelium and secrete pulmonary surfactant. Pulmonary surfactant coats the alveoli &small bronchioles and prevents collapsing.

Mechanisms of atelectasis. A, Collapse of the lung in pneumothorax. B, Compression of the lung by pleural fluid. C, Resorption of the air from alveoli distal to an obstructed bronchus. Obstructive atelectasis is usually focal. Atelectasis of premature infants, which is caused by a deficiency of pulmonary surfactant, is not shown

Mechanisms of atelectasis. A, Collapse of the lung in pneumothorax. B, Compression of the lung by pleural fluid. C, Resorption of the air from alveoli distal to an obstructed bronchus. Obstructive atelectasis is usually focal. Atelectasis of premature infants, which is caused by a deficiency of pulmonary surfactant, is not shown

October 2012 - The EMBO Journal     Giant proteo-liposomes of pulmonary surfactant, material that lines the alveoli of mammals and allows breathing. Each vesicle is 20-50µm in diameter and contains fluorescent dyes highlighting the preferred localization and packing properties of the surfactant lipids and proteins in the membrane. (Credit: Jorge Bernardino de la Serna, EMBOJ) #NPG Nature Publishing Group

October 2012 - The EMBO Journal Giant proteo-liposomes of pulmonary…

Phosphatidylglycerol is a glycerophospholipid found in pulmonary surfactant. It is the precursor of surfactant and its presence (>0.3) in the amniotic fluid of the newborn indicates fetal lung maturity.

Phosphatidylglycerol is a glycerophospholipid found in pulmonary surfactant. It is the precursor of surfactant and its presence in the amniotic fluid of the newborn indicates fetal lung maturity.

Each photomicrography shows a giant liposomes ~20-50µm in diameter comprised of fats and proteins from the surface of the mammalian lung alveoli without any chemical treatment. [Cell Press]

photomicrography of giant liposomes in diameter) comprised of fats and proteins from the surface of the mammalian lung alveoli without any chemical treatment - One of the most ambitious endeavours of synthetic biology is creating “minimal cells”

Victorial Wallpaper in Your Lungs: Microscopic image of what happens to the surfactant in the lungs when it comes into contact with inhaled carbon nanoparticles. Read more at Scientific American | http://blogs.scientificamerican.com/symbiartic/2013/04/08/victorian-wallpaper-lungs/?WT_mc_id=SA_DD_20130409

This elegant black-and-white pattern is a microscopic image that used fluorescent dye to reveal the patterns made by lung surfactant, a soaplike material that covers the inside of the lungs. Without surfactant, the lungs would collapse.

As Airway Therapeutics pursues development of a major improvement in artificial surfactant, the start-up company offers a valuable lesson in what it takes to cross the drug development “funding desert.” The new company’s product is based on research by Jeff Whitsett, MD, chief of the Division of Neonatology Perinatal and Pulmonary Biology at Cincinnati Children's.

As Airway Therapeutics pursues development of a major improvement in artificial surfactant, the start-up company offers a valuable lesson in what it takes to cross the drug development “funding desert.” The new company’s product is based on research by Jeff Whitsett, MD, chief of the Division of Neonatology Perinatal and Pulmonary Biology at Cincinnati Children's.

Discovery Laboratories, Inc., a specialty biotechnology company, focuses on developing products for critical-care patients with respiratory disease and improving care in pulmonary medicine. Its proprietary drug technology produces a synthetic peptide-containing surfactant (KL4 surfactant in liquid, lyophilized, and aerosolized dosage forms)

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The_production_of_pulmonary_surfactant.jpg

Surface tension increases the tendency of the alveoli to collapse. Surfactant decreases the surface tension in the lungs and thus decrease the work of breathing, minimizes collapse and oedema.

#Biological #Drugs now can be made with #Spider #Silk #Protein  Biological Drugs now can be made with Spider Silk Protein  Researchers have managed to synthesise lung surfactant a drug used in the care of preterm babies by mimicking the production of spider milk. It is as effective as the biological drugs currently in clinical use.  SWEDEN 23rd May : Researchers atKarolinska Institutetin Sweden have managed to synthesise lung surfactant a drug used in the care ofpreterm babies by mimicking…

Biological Drugs now can be made with Spider Silk Protein Researchers have managed to synthesise lung surfactant, a drug used in the.

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