Sideroblastic Anemia - STEP1 Heme - Step 1 - Medbullets.com

Sideroblastic Anemia - STEP1 Heme - Step 1 - Medbullets.com

A ringed sideroblast must have 10 siderosomes surroundng at least one-third the nucleus.  Can be seen in ETOH, pyrazinamide, lead and benzene.

A ringed sideroblast must have 10 siderosomes surroundng at least one-third the nucleus. Can be seen in ETOH, pyrazinamide, lead and benzene.

Special Types Of Anemia: Sideroblastic Anemias And Paroxysmal Nocturnal Hemoglobinuria (PNH)

Special Types Of Anemia: Sideroblastic Anemias And Paroxysmal Nocturnal Hemoglobinuria (PNH)

Sideroblastic anemia - Causes, Diagnosis, Treatment, Ongoing care and Clinical pearls

[MEGALOBLASTIC ANEMIA]. Coarse basophilic stippling is also a morphologic feature of MA but not specific to this disease and can be seen in other disorders including lead poisoning, sideroblastic anemia, thalassemia, certain hemoglobinopathies, and pyrimidine 5` nucleotidase deficiency. Defective DNA synthesis is also seen in congenital deficiency of certain enzymes including dihydrofolate reductase and methyltransferase.

[MEGALOBLASTIC ANEMIA]. Coarse basophilic stippling is also a morphologic feature of MA but not specific to this disease and can be seen in other disorders including lead poisoning, sideroblastic anemia, thalassemia, certain hemoglobinopathies, and pyrimidine 5` nucleotidase deficiency. Defective DNA synthesis is also seen in congenital deficiency of certain enzymes including dihydrofolate reductase and methyltransferase.

Pappenheimer Bodies = iron granules (sideroblastic anemia)

Pappenheimer Bodies = iron granules (sideroblastic anemia)

Pappenheimer (e.g. in sideroblastic anemia) vs. Howell-jolly body (e.g. in sickle cell)

Pappenheimer (e.g. in sideroblastic anemia) vs. Howell-jolly body (e.g. in sickle cell)

Ringed sideroblast sideroblastic anemia

Ringed sideroblast sideroblastic anemia

Sideroblastic anemia

Sideroblastic anemia

Iron Metobolism : When we eat iron, we generally get it in one of two forms: elemental iron or heme (from meat). In the intestine (proximal duodenum to be precise) the iron is either absorbed or actively transferred in. Iron is transported in the blood bound to transferrin and is stored in the liver bound to ferritin. This is why ferritin is measured when assessing iron stores.  Though most of the time you can make the diagnosis of iron deficiency anemia by assessing the patient’s history…

When we eat iron, we generally get it in one of two forms: elemental iron or heme (from meat). In the intestine (proximal duodenum to be precise) the iron is either absorbed or actively transferred.

Ring Sideroblasts in Sideroblastic Anemia. BM.

Ring Sideroblasts in Sideroblastic Anemia.

sideroblastic anemia = ringed sideroblasts in BM; low MCHC, bimodal RDW; iron indices all high (serum iron, transferrin, ferritin)

Sideroblastic anemia with ringed sideroblasts

Sideroblastic anemia

Sideroblastic anemia

Pappenheimer bodies = IRON granules in mitochondria = sideroblastic anemia and asplenism.

Pappenheimer bodies = IRON granules in mitochondria = sideroblastic anemia and asplenism.

21 DIY Home Remedies for Anemia - http://www.myeffecto.com/r/1yid_pn

21 DIY Home Remedies for Anemia - http://www.myeffecto.com/r/1yid_pn

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