De novo mutations of voltage-gated sodium channel alphaII gene SCN2A in intractable epilepsies.  - PubMed - NCBI

De novo mutations of voltage-gated sodium channel alphaII gene SCN2A in intractable epilepsies. - PubMed - NCBI

Structural analysis of the eel Nav1.4 channel offers insights into the electromechanical coupling mechanism of voltage-gated sodium channels.

Structural analysis of the eel Nav1.4 channel offers insights into the electromechanical coupling mechanism of voltage-gated sodium channels.

The role of sodium channels in chronic pain

The role of sodium channels in chronic pain - Levinson - 2012 - Muscle & Nerve

Cardiac Terms: positive/negative inotrope Type: Term Definitions: 1. an agent or medication, or its side effects, which may effectuate either to strengthen (positive) or weaken (negative) the force of a functional system (usually the contractility of the heart). positive/negative chronotrope Type: Term Pronunciation: poz′i-tiv-neg′ă-tiv kroō′nō-trōp Definitions: 1. an agent or medication, or its side effects, which may effectuate to either slow (negative) or accelerate (positive) the rate of…

Cardiac Terms: positive/negative inotrope Type: Term Definitions: 1. an agent or medication, or its side effects, which may effectuate either to strengthen (positive) or weaken (negative) the force of a functional system (usually the contractility of the heart). positive/negative chronotrope Type: Term Pronunciation: poz′i-tiv-neg′ă-tiv kroō′nō-trōp Definitions: 1. an agent or medication, or its side effects, which may effectuate to either slow (negative) or accelerate (positive) the rate of…

Now where was I.   If you remember we have been examining how nerves fire. It is important because all of the problems of MS are caused by the nerves not functioning well enough or because they are over excited and firing too much. I got a bit side tracked by the B cell story. So to recap When a nerve impulse is transmitted it moves because of the action of sodium channels. The outside of the cell is normally more electrically positive than the inside of the cell.  So when the stimulus comes…

Now where was I. If you remember we have been examining how nerves fire. It is important because all of the problems of MS are caused by the nerves not functioning well enough or because they are over excited and firing too much. I got a bit side tracked by the B cell story. So to recap When a nerve impulse is transmitted it moves because of the action of sodium channels. The outside of the cell is normally more electrically positive than the inside of the cell. So when the stimulus comes…

Early records, since the the time of the Meiji ruling class in Japan (1868–1912), show prohibitions and restrictions limiting the sale of fugu. Only licensed chefs can prepare this fish as it is necessary to remove the ovaries and liver where the poison resides. It is the most poisonous fish in the world. A lethal dose is only one milligram. That is a very tiny amount that can fit on a pinhead. A typical mature fugu contains thirty times that amount. The poison acts by blocking sodium…

Pufferfish, Blowfish, Fugu - Poison Sushi?

Pufferfish, Blowfish, Fugu - something very strange you might like to eat but be very careful only licensed chefs should prepare this possibly toxic meal.

Structure of Sodium Channels Different from What Believed Previously

Despite Urgent Calls for Reducing Consumption, Rise Noted in Sodium Intake in US Over Last Decade

Procainamide (Pronestyl, Procan, Procanbid) is an antiarrhythmic used for cardiac arrhythmias, classified as class Ia. It is a sodium channel blocker which blocks open sodium channels and prolongs the cardiac action potential (outward potassium (K+) currents may be blocked). This results in slowed conduction, and ultimately the decreased rate of rise of the action potential, which may result in widening of QRS on electrocardiogram. It is a hapten. It is metabolized by N-acetyltransferase.

Procainamide (Pronestyl, Procan, Procanbid) is an antiarrhythmic used for cardiac arrhythmias, classified as class Ia. It is a sodium channel blocker which blocks open sodium channels and prolongs the cardiac action potential (outward potassium (K+) currents may be blocked). This results in slowed conduction, and ultimately the decreased rate of rise of the action potential, which may result in widening of QRS on electrocardiogram. It is a hapten. It is metabolized by N-acetyltransferase.

Mechanism of action of sodium channel blocker insecticides (SCBIs) on insect sodium channels

Mechanism of action of sodium channel blocker insecticides (SCBIs) on insect sodium channels

Read about a study reporting that heart arrhythmia in myotonic dystrophy (DM) patients is caused by mutant RNA in the heart’s sodium channel.

Heart Arrhythmia in Myotonic Dystrophy Patients Traced to Mutant RNA in Study

Gut flora composition linked to health, diet, and lifestyle, pioneering population study reveals

The resting membrane potential of minus seventy volts is maintained by a sodium/potassium transporter that transports sodium ions out of the cell and potassium ions in. Voltage gated sodium and potassium channels are closed. In response to a nerve impulse, some sodium channels open, allowing sodium ions to enter the cell. The membrane starts to depolarize; in other words, the charge across the membrane lessens. If the membrane potential increases to the threshold of excitation, all the…

This diagram shows how sodium and potassium ions are pumped through protein channels. The sodium ions are pumped out of the cell, while potassium is pumped into the cell. The movement of these ions creates resting potential and action potential.

The heterozygous mutations in the cardiac voltage-gated sodium channel α-subunit gene (SCN5A) have been implicated in rare, familial types of Brugada Syndrome

The implications of genetic mutations in the sodium channel gene

Graph plots membrane potential in millivolts versus time. The membrane remains at the resting potential of -70 millivolts until a nerve impulse occurs in step 1. Some sodium channels open, and the potential begins to rapidly climb past the threshold of excitation of -55 millivolts, at which point all the sodium channels open. At the peak action potential, the potential begins to rapidly drop as potassium channels open and sodium channels close. As a result, the membrane repolarizes past the…

Learn more about nerve impulse transmission within a neuron: action potential in the Boundless open textbook. Signals are transmitted from neuron to neuron via an action potential, when the axon membrane rapidly depolarizes and repolarizes.

Flecainide works to control the rhythm of the heart by inhibiting fast sodium channels and reducing the conduction and contractility of the heart muscle.

How dose Flecainide work

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