The central character is Dr. Gregory House (Hugh Laurie), an unconventional and misanthropic medical genius who heads a team of diagnosticians at the fictional Princeton-Plainsboro Teaching Hospital (PPTH) in New Jersey.
Gregory House said, "You know, I get it. That people are just looking for ways to fill the holes. But they want the holes. They want to live in the holes. And they go nuts when someone else pours dirt in their holes. Climb out of your holes, people!