Working with epirubicin today in the lab. This is one of the standard drugs in the neoadjuvant cocktail of chemotherapies for IBC. It is in the same family as doxorubicin (often called "red devil" by pts for obvious reasons!) so you will usually get 1 or the other. How does it work? It has several mechanisms, including generating DNA and oxidative damage which kill cells at a certain threshold.Unfortunately it is usually the drug which causes hair loss, neutropenia & is pretty nauseating :(
Inflammatory breast cancer (IBC) is a rare, aggressive type of breast cancer that compromises 1-5% of all newly diagnosed breast cancers. Physician recognition and early diagnosis of IBC are critical because the overall survival rate is lower for it than for other breast cancers (50%).