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Sunday survey - Peripheral Blood Cell Morphology

Sunday survey - Peripheral Blood Cell Morphology

[ACUTE MYELOGENOUS LEUKEMIA, M0, BLOOD]. A myeloblast of an AML-M0 is compared to a medium-sized normal lymphocyte. Note the presence of only very scant cytoplasm in a blast and finer evenly-distributed chromatin in comparison to a lymphocyte. The high nuclear to cytoplasmic ration (N/C ratio) is a common albeit not a required feature of blasts. The single defining morphologic feature of a blast is it’s finely distributed nuclear chromatin.

[ACUTE MYELOGENOUS LEUKEMIA, M0, BLOOD]. A myeloblast of an AML-M0 is compared to a medium-sized normal lymphocyte. Note the presence of only very scant cytoplasm in a blast and finer evenly-distributed chromatin in comparison to a lymphocyte. The high nuclear to cytoplasmic ration (N/C ratio) is a common albeit not a required feature of blasts. The single defining morphologic feature of a blast is it’s finely distributed nuclear chromatin.

Medical Laboratory and Biomedical Science: Weekend Haematology Challenge

Medical Laboratory and Biomedical Science: Weekend Haematology Challenge

A 67-year-old female presents with pancytopenia, a markedly enlarged spleen, and extramedullary hematopoiesis. Her blood smear is shown here. She is found to have a JAK-2 mutation. What is the diag...

A 67-year-old female presents with pancytopenia, a markedly enlarged spleen, and extramedullary hematopoiesis. Her blood smear is shown here. She is found to have a JAK-2 mutation. What is the diag...

CMML: This patient has a peripheral blood monocytosis, a hypercellular bone marrow, and dysplastic neutrophils, monocytes, and megakaryocytes.  In addition to persistent monocytosis, the 2008 WHO diagnostic criteria for CMML include: the absence of a Philadelphia chromosome or BCR-ABL1 fusion gene; the absence of a rearrangement for PDGFRA or PDGFRB; <20% blasts in the blood and bone marrow; and dysplasia in one or more myeloid lineages.

CMML: This patient has a peripheral blood monocytosis, a hypercellular bone marrow, and dysplastic neutrophils, monocytes, and megakaryocytes. In addition to persistent monocytosis, the 2008 WHO diagnostic criteria for CMML include: the absence of a Philadelphia chromosome or BCR-ABL1 fusion gene; the absence of a rearrangement for PDGFRA or PDGFRB; <20% blasts in the blood and bone marrow; and dysplasia in one or more myeloid lineages.

Components of blood - In order of most predominant cell: "Naked Ladies Make Everything Better" (Neutrophils, Lymphocytes, Monocytes, Eosinophils, Basophils)

Acute lymphocytic leukemia

Acute lymphocytic leukemia

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