Simonetta Vespucci,1480-85 by Boticelli. Simonetta Cattaneo de Candia Vespucci (ca. 1453 – 26 April 1476), nicknamed la bella Simonetta, was an Italian Renaissance noblewoman from Genoa and the wife of Marco Vespucci of Florence. She was renowned for being the greatest beauty of her age - certainly of the city of Florence.
Giotto di Bondone, born Angiolo di Bondone, also called Angiolotto, ca 1267–8Jan1337 | The Virgin and Child | The later 16th century biographer Giorgio Vasari says of him "...He made a decisive break with the ...Byzantine style, and brought to life the great art of painting as we know it today, introducing the technique of drawing accurately from life, which had been neglected for more than two hundred years."
Jan van Eyck, c.1432. Ghent Altarpiece. Opened view of the polyptych. Commissioned by the wealthy merchant and financier Joost Vijdt for his and his wife's private chapel, it was begun by Hubert van Eyck, who died in 1426, and completed by his younger brother Jan van Eyck. The altarpiece shows a transition in art from the Classical tradition to an exacting observation of nature. The altarpiece consists of a total of 24 compartmented scenes, which make up two views, open and closed,